Ammonia → HCID 86689712, compound

HRID 1396341Notes

Reaction equation

HRID 1396341 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8](OC)=[O:9])=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][N:14]=2)[CH:3]=1.[NH3:23]>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]([NH2:23])=[O:9])=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][N:14]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 86689711Methyl 6-chloro-4-(5-(methylsulfonyl)pyridin-2-ylamino)pyridazine-3-carboxylate

Product 1

HCID 86689712HCID 86689712, compoundYield 101.1%

Procedure

Methyl 6-chloro-4-(5-(methylsulfonyl)pyridin-2-ylamino)pyridazine-3-carboxylate (62 mg, 0.181 mmol) was suspended in ammonia (7M in methanol, 3.94 g, 5 mL, 35.0 mmol). The reaction vessel was sealed. After 18 h, the mixture was concentrated in vacuo to give 6-chloro-4-(5-(methylsulfonyl)pyridin-2-ylamino)pyridazine-3-carboxamide (60 mg, 100%) as an off-white solid that was used directly in the next step without further purification.

Workup

  1. customThe reaction vessel was sealed
  2. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-5ee5c867722147f0a921085b86f91e44
Source dataset
uspto-grants-2014_12
Patent number
US08901124B2

Reaction notes

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