反应详情

Methyl 6-chloro-4-(5-(methylsulfonyl)pyridin-2-ylamino)pyridazine-3-carboxylate (62 mg, 0.181 mmol) was suspended in ammonia (7M in methanol, 3.94 g, 5 mL, 35.0 mmol). The reaction vessel was sealed. After 18 h, the mixture was concentrated in vacuo to give 6-chloro-4-(5-(methylsulfonyl)pyridin-2-ylamino)pyridazine-3-carboxamide (60 mg, 100%) as an off-white solid that was used directly in the next step without further purification.

1. customThe reaction vessel was sealed
2. concentrationthe mixture was concentrated in vacuo