反应详情

This compound was prepared according to general method D from methyl-2-(4-phenyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate (0.018 g; 0.041 mmol), sodium hydroxide 5N (0.100 mL; 0.50 mmol) in methanol (1 mL) at 60° C. for 72 h. The reaction mixture was concentrated under reduced pressure, the residue was dissolved in water and extracted with diethyl ether. The pH of the aqueous layer was adjusted between 2 and 3 by addition of a solution of hydrochloric acid 6N until a precipitate was formed. The suspension was extracted twice with ethyl acetate and the combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to give 0.012 g (68%)of the title compound.

1. customThis compound was prepared
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. dissolutionthe residue was dissolved in water
4. extractionextracted with diethyl ether
5. additionThe pH of the aqueous layer was adjusted between 2 and 3 by addition of a solution of hydrochloric acid 6N until a precipitate
6. customwas formed
7. extractionThe suspension was extracted twice with ethyl acetate
8. dry with materialthe combined organic layers were dried over sodium sulfate
9. concentrationconcentrated under reduced pressure