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HRID1401015

反应详情

EQUATION

反应方程式

HRID 1401015 的结构方程式

REACTANTS

反应物

2
结构：C=C(C)[C@@H]1CC[C@]2(NCCN3CCC(S(C)(=O)=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(OS(=O)(=O)C(F)(F)F)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12
HCID71698667

未命名化合物

结构：CC1(C)OB(C2=CCC3(CCOC3=O)CC2)OC1(C)C
HCID86692369

未命名化合物

PRODUCTS

生成物

1
结构：C=C(C)[C@@H]1CC[C@]2(NCCN3CCC(S(C)(=O)=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CCC7(CCOC7=O)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12
HCID86692370

未命名化合物

收率 59%

PROCEDURE

实验过程

The title compound was prepared following the procedure described in general procedure Step 5, using (1R,3 aS,5aR,5bR,7aR,11aR,11bR,13 aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-((2-(4-(methylsulfonyl)piperidin-1-yl)ethyl)amino)-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl trifluoromethanesulfonate and 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-oxaspiro[4.5]dec-7-en-1-one as reactants. The product was isolated as diastereomers (solid, 59% yield). MS: m/e 749.7 (M+H)+, 4.10 min (method 7). 1H NMR (400 MHz, CHLOROFORM-d) δ 5.35 (d, J=2.8 Hz, 1H), 5.24-5.19 (m, 1H), 4.72 (d, J=2.0 Hz, 1H), 4.59 (dd, J=2.3, 1.5 Hz, 1H), 4.37-4.25 (m, 2H), 3.12 (dd, J=14.6, 12.0 Hz, 2H), 2.87-2.78 (m, 1H), 2.84 (s, 3H), 2.67-2.53 (m, 3H), 2.50-2.40 (m, 3H), 2.33-0.90 (m, 35H), 1.70 (s, 3H), 1.09 (s, 3H), 0.98-0.92 (m, 6H), 0.96 (s, 3H), 0.86 (s, 3H).

WORKUP

后处理

  1. customThe product was isolated as diastereomers (solid, 59% yield)
  2. customm/e 749.7 (M+H)+, 4.10 min (method 7)