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HRID1401029

反应详情

EQUATION

反应方程式

HRID 1401029 的结构方程式

REACTANTS

反应物

2
结构：C=C(C)[C@@H]1CC[C@]2(NCCN3CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(OS(=O)(=O)C(F)(F)F)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12
HCID71698666

未命名化合物

结构：CCOC(=O)C1C2C=C(B3OC(C)(C)C(C)(C)O3)CC21
HCID86692388

未命名化合物

PRODUCTS

生成物

1
结构：C=C(C)[C@@H]1CC[C@]2(NCCN3CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC7C(C6)C7C(=O)OCC)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12
HCID86692390

未命名化合物

PROCEDURE

实验过程

The title compound was prepared following the method described in step 1 for the preparation of Example 1, using (1R,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl trifluoromethanesulfonate and ethyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)bicyclo[3.1.0]hex-2-ene 6-carboxylate as the reactants. The title compound was obtained as a mixture of diastereomers in 54% yield. MS: m/e 721.55 (M+H)+, 2.901 min (method 8). 1H NMR (400 MHz, CHLOROFORM-d) δ 5.81 (dd, J=6.3, 1.5 Hz, 1H), 5.50-5.37 (m, 1H), 4.72 (d, J=2.0 Hz, 1H), 4.60 (d, J=0.8 Hz, 1H), 4.19-4.05 (m, 3H), 3.11-3.00 (m, 7H), 2.97-2.82 (m, 1H), 2.74-2.43 (m, 6H), 2.17 (td, J=6.6, 3.1 Hz, 1H), 2.09-2.01 (m, 2H), 2.00-1.73 (m, 3H), 1.70 (s, 3H), 1.66-1.18 (m, 20H), 1.16-1.01 (m, 11H), 0.97 (m, 3H), 0.83 (m, 3H).

WORKUP

后处理

  1. customThe title compound was prepared
  2. customdescribed in step 1 for the preparation of Example 1