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HRID1401041

反应详情

EQUATION

反应方程式

HRID 1401041 的结构方程式

REACTANTS

反应物

2
结构：C=C(C)[C@@H]1CC[C@]2(NCCN3CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(OS(=O)(=O)C(F)(F)F)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12
HCID71698666

未命名化合物

结构：COC(=O)C1(NC(C)=O)CC=C(B2OC(C)(C)C(C)(C)O2)CC1
HCID86692402

未命名化合物

PRODUCTS

生成物

1
结构：C=C(C)[C@@H]1CC[C@]2(NCCN3CCS(=O)(=O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CCC(NC(C)=O)(C(=O)OC)CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12
HCID86692403

未命名化合物

收率 65.7%

PROCEDURE

实验过程

The title compound was prepared following the method described in step 1 for the preparation of Example 1, using (1R,3aS,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl trifluoromethanesulfonate and methyl 1-acetamido-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate as the reactants. The product was obtained as a mixture of diastereomers in 65.7% yield. MS: m/e 766.8 (M+H)+, 2.72 min (method 3). 1H NMR (400 MHz, CHLOROFORM-d) δ 5.82 (d, J=3.0 Hz, 1H), 5.26 (br. s., 1H), 5.21-5.12 (m, 1H), 4.70 (d, J=2.0 Hz, 1H), 4.58 (d, J=1.3 Hz, 1H), 3.78-3.68 (m, 3H), 3.14-2.90 (m, 7H), 2.75-2.42 (m, 6H), 2.40-2.19 (m, 3H), 2.13-2.05 (m, 1H), 1.98 (d, J=2.0 Hz, 3H), 1.95-1.69 (m, 6H), 1.68 (s, 3H), 1.65-1.30 (m, 7H), 1.25 (m, 11H), 1.10-1.01 (m, 6H), 0.98-0.87 (m, 6H), 0.87-0.83 (m, 3H).

WORKUP

后处理

  1. customdescribed in step 1 for the preparation of Example 1
  2. customThe product was obtained as a mixture of diastereomers in 65.7% yield
  3. customm/e 766.8 (M+H)+, 2.72 min (method 3)