反应详情

6.12 g (12.28 mmol) of 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and 3 g (12.28 mmol) of 4-thiocarbamoylpiperidine-1-carboxylic acid tert-butyl ester were suspended in 50 ml of ethanol and refluxed overnight. The reaction mixture was cooled and evaporated. The residue was slurried using a little EA and PE, digested and filtered off with suction. The solid was suspended in 180 ml of EA, washed with 60 ml of a saturated sodium hydrogencarbonate solution. The organic phase was dried over sodium sulfate, filtered and evaporated.

1. temperaturerefluxed overnight
2. temperatureThe reaction mixture was cooled
3. customevaporated
4. filtrationfiltered off with suction
5. washwashed with 60 ml of a saturated sodium hydrogencarbonate solution
6. dry with materialThe organic phase was dried over sodium sulfate
7. filtrationfiltered
8. customevaporated