反应详情

To a solution of 2-(2-acetyl-4-bromophenoxy)acetic acid (5.3 g, 19.41 mmol) in acetic anhydride (100 mL) was added NaOAc (3.19 g, 38.90 mmol). The resulting solution was heated to reflux overnight. The pH value of the resulting solution was adjusted to 7 with aqueous sodium hydroxide, extracted with ether (50 mL×3), dried over anhydrous sodium sulfate and concentrated under vacuum to give a residue, which was purified by silica gel chromatography (petroleum ether) to afford 5-bromo-3-methyl-1-benzofuran as a light yellow oil (3.8 g, 93%).

1. temperatureThe resulting solution was heated
2. temperatureto reflux overnight
3. extractionextracted with ether (50 mL×3)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated under vacuum
6. customto give a residue, which
7. customwas purified by silica gel chromatography (petroleum ether)