反应详情

To a solution of the tert-butyl 4-[(6′-amino-5′-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}-3,3′-bipyridin-6-yl)oxy]piperidine-1-carboxylate (115 mg, 0.2 mmol) in MeOH (1 mL) was added HCl (4N in dioxane, 1 mL). The mixture was stirred at room temperature for 1 hr. The mixture was concentrated and the residue purified by a reversed phase prep-HPLC. The desired fractions were lyophillized to give the title compound (61 mg) as an off-white solid.

1. concentrationThe mixture was concentrated
2. customthe residue purified by a reversed phase prep-HPLC