HRID1406408

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11665716

未命名化合物

HCID43565332

未命名化合物

反应SMILES：Cc1c(N)cc(-c2cc3ccccc3n2C(=O)OC(C)(C)C)c(=O)n1COCC[Si](C)(C)C

HCID58117460

未命名化合物

2 次

PRODUCTS

产物

反应SMILES：Cc1c(NC(=O)c2cnn(Cc3cccc(F)c3)c2)cc(-c2cc3ccccc3n2C(=O)OC(C)(C)C)c(=O)n1COCC[Si](C)(C)C

HCID58117360

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the experimental used in Example 20, Step 4 with intermediate (7d), 2-[5-amino-6-methyl-2-oxo-1-(2-trimethylsilanyl-ethoxymethyl)-1,2-dihydropyridin-3-yl]indole-1-carboxylic acid tert-butyl ester, and 1-(3-Fluoro-benzyl)-1H-pyrazole-4-carboxylic acid, which was synthesised according to the protocol described for intermediate (6e) in Example 21. The resultant crude product was purified by flash chromatography on SiO2 with hexane—50% ethyl acetate/hexane (gradient) to afford the title compound as a yellow oil, 80 mg, 70%.

WORKUP

后处理

customThe title compound was prepared
customwas synthesised
customThe resultant crude product was purified by flash chromatography on SiO2 with hexane—50% ethyl acetate/hexane (gradient)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-3e9c65bde68e47d8a49010aa78f2f86c
来源数据集: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08916591B2
来源说明: uspto-grants-2014_12

反应SMILES

[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:17]1[C:18](=[O:33])[N:19]([CH2:25][O:26][CH2:27][CH2:28][Si:29]([CH3:32])([CH3:31])[CH3:30])[C:20]([CH3:24])=[C:21]([NH2:23])[CH:22]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:34][C:35]1[CH:36]=[C:37]([CH:47]=[CH:48][CH:49]=1)[CH2:38][N:39]1[CH:43]=[C:42]([C:44](O)=[O:45])[CH:41]=[N:40]1.FC1C=CC(CN2C=C(C(O)=O)C=N2)=CC=1>>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[C:9]1[C:17]1[C:18](=[O:33])[N:19]([CH2:25][O:26][CH2:27][CH2:28][Si:29]([CH3:30])([CH3:32])[CH3:31])[C:20]([CH3:24])=[C:21]([NH:23][C:44]([C:42]2[CH:41]=[N:40][N:39]([CH2:38][C:37]3[CH:47]=[CH:48][CH:49]=[C:35]([F:34])[CH:36]=3)[CH:43]=2)=[O:45])[CH:22]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]