反应详情

To 20 ml of dichloroethane and 10 ml of formic acid were added 2 g of ethyl 8-chloro-6,7-difluoro-1-(2,4-difluoro-5-nitrophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate and 200 mg of 10% palladium on carbon. Under a hydrogen atmosphere, the solution was stirred at room temperature for 3 hours and after addition of acetic anhydride, further stirred overnight. The catalyst was removed by a membrane filter and the filtrate was concentrated in vacua. Diethyl ether was added to the residue whereupon the solid was collected by filtration and washed with ethanol and diethyl ether to give 1.9 g of the title compound.

1. customThe catalyst was removed by a membrane
2. filtrationfilter
3. concentrationthe filtrate was concentrated in vacua
4. additionDiethyl ether was added to the residue whereupon the solid
5. filtrationwas collected by filtration
6. washwashed with ethanol and diethyl ether