反应详情

A solution was prepared by dissolving 10 mg (0.019 mmol) of (3S,5R,6S,7S)-7-(benzyloxymethyl)-6-(4-fluorophenyl)-3-hydroxy-3-(2-methoxy-5-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]nonane in 0.20 mL of trifluoroacetic acid at RT, and triethylsilane (0.009 mL, 7 mg, 0.06 mmol) was added immediately. After 30 min., the reaction was diluted with 25 mL of ethyl acetate and washed with 5 m L of saturated aqueous sodium bicarbonate and 5 mL of saturated aqueous sodium chloride. The organic solution was dried over sodium sulfate, decanted, and evaporated. The crude product was purified by preparative TLC, eluting with 3% ethyl ether in toluene, to yield 2.4 mg of the title compound.

1. customA solution was prepared
2. washwashed with 5 m L of saturated aqueous sodium bicarbonate and 5 mL of saturated aqueous sodium chloride
3. dry with materialThe organic solution was dried over sodium sulfate
4. customdecanted
5. customevaporated
6. customThe crude product was purified by preparative TLC
7. washeluting with 3% ethyl ether in toluene