反应详情

350 mg of 6-benzyloxy-4-methoxymethyl-9-{6-[N-methyl-N-(2-phenylethyl)-amino]-2-oxohexyl}-9H-pyrido[3,4-b]indole-3-carboxylic acid-(1-methylethyl)-ester (0.55 mmol) is mixed in 10 ml of methanol with 1 ml of 2N aqueous sodium hydroxide solution and held at 40° C. until the reaction is completed. Then, the reaction mixture is acidified with dilute hydrochloric acid, and the precipitated product is suctioned off. It is washed with water and then with diethyl ether, dried in a vacuum, and 212 mg of 6-benzyloxy-4-methoxymethyl-9-{6-[N-methyl-N-(2-phenylethyl)-amino]-2-oxohexyl}-9H-pyrido-[3,4-b]-indole-3-carboxylic acid is obtained as a yellow, amorphous powder.

1. customheld at 40° C. until the reaction
2. washIt is washed with water
3. dry with materialwith diethyl ether, dried in a vacuum