2,2,6,6-Tetramethylpiperidine → 1-(tert-Butoxycarbonyl)indole-2-boronic Acid (contains varying amounts of Anhydride)

Temperature

-75 °C

To a solution of 2,2,6,6-tetramethylpiperidine (11.0 g; 78 mmols) in THF (170 ml), at -78° C. and under nitrogen, a 1.6M solution of BuLi (56.1 ml; 89.7 mmols) in hexane is added slowly in order to maintain the temperature below -65° C. The mixture is stirred at -75° C. for 10 min and is then warmed to 0° C. within 30 min. After cooling again to -78° C., a solution of 1-tert-butoxycarbonylindole (15.6 g; 72 mmols) in THF (300 ml) is added, keeping the temperature below -65° C. The mixture is stirred 1 hour at -75° C. and a solution of trimrthyl borate (7.5 g; 72 mmols) in THF (200 ml) is added dropwise. The reaction is allowed to warm up to room temperature overnight. A 0.25N solution of Hcl (200 ml) is added and the THF is removed under vacuum. The residue is extracted with ethyl ether (3×150 ml) and the combined organic phases are washed with water (2×100 ml) and dried over sodium sulphate. The solution is then concentrated, cooled to 0° C. and filtered to obtain crystalline (1-tert-butoxycarbonylindol-2-yl)boronic acid (6.95 g; 26.6 mmols). Yield: 37%.

1. temperatureto maintain the temperature below -65° C
2. temperatureis then warmed to 0° C. within 30 min
3. temperatureAfter cooling again to -78° C.
4. customthe temperature below -65° C
5. stirringThe mixture is stirred 1 hour at -75° C.
6. temperatureto warm up to room temperature overnight
7. customthe THF is removed under vacuum
8. extractionThe residue is extracted with ethyl ether (3×150 ml)
9. washthe combined organic phases are washed with water (2×100 ml)
10. dry with materialdried over sodium sulphate
11. concentrationThe solution is then concentrated
12. temperaturecooled to 0° C.
13. filtrationfiltered

ORD record

ord-7e0145bf9e7c438a904b62c6f7083ae6

Source dataset

uspto-grants-2000_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06071947