反应详情

At 0° C., tert-butyl 4-(8-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(6-fluoroquinolin-3-yl)-7-methyl-5H-pyrazolo[1,5-a]pyrrolo[2,3-d]pyrimidin-5-yl)piperidine-1-carboxylate (95 mg, 0.12 mmol) was treated with 80% TFA/H2O (5 mL). After stirring at room temperature for 30 min, concentration afforded crude 3-(6-fluoroquinolin-3-yl)-7-methyl-5-(piperidin-4-yl)-5H-pyrazolo[1,5-a]pyrrolo[2,3-d]pyrimidin-8-amine which was used for next step without further purification. LCMS is =0.69 Min (5 min run, UV254nm), Mass calculated for M+415.2, observed m/z 416.2 (M+H).

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