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HRID1424203

反应详情

EQUATION

反应方程式

HRID 1424203 的结构方程式

REACTANTS

反应物

2
结构：CCCC[N+](CCCC)(CCCC)CCCC.[F-]
HCID2724141

Tetra-n-butylammonium fluoride

C16H36FN

结构：C[C@H]1C(=O)N([Si](C)(C)C(C)(C)C)[C@@H]1c1cn2cc(C(C)(C)C)ccc2n1
HCID86699118

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1C(=O)N[C@@H]1c1cn2cc(C(C)(C)C)ccc2n1
HCID86699117

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

PROCEDURE

实验过程

(3R,4S)-4-(6-(tert-butyl)imidazo[1,2-a]pyridin-2-yl)-1-(tert-butyldimethylsilyl)-3-methylazetidin-2-one (Preparation 40) was dissolved in THF and 1 M tetrabutylammonium fluoride in THF (3 mL, 10 mmol) was added. The reaction mixture was stirred for 2 hours then the solvent was removed in vacuo. The intermediate was purified by silica gel column chromatography eluting with 0-100% CMA80 in dichloromethane to afford the title compound.

WORKUP

后处理

  1. customthe solvent was removed in vacuo
  2. customThe intermediate was purified by silica gel column chromatography
  3. washeluting with 0-100%