反应详情

2-(4-Methylthiazol-2-ylamino)pyridin-3-ol (prepared according to Example 3, Step A; 75 mg, 0.362 mmol), 3-(bromomethyl)pyridine hydrochloride (75.4 mg, 0.362 mmol) and potassium carbonate (175 mg, 1.27 mmol) were reacted according to Example 3, Step B, to provide N-(4-methylthiazol-2-yl)-3-(pyridin-3-ylmethoxy)pyridin-2-amine dihydrochloride (67 mg, 49.9% yield) as a tan solid. 1H NMR (d6-DMSO) δ 10.15 (bs, 1H), 8.82 (s, 1H), 8.57 (d, 1H), 8.07 (m, 1H), 7.88 (dd, 1H), 7.46 (m, 2H), 6.92 (dd, 1H), 6.58 (s, 1H), 5.29 (s, 2H), 2.24 (s, 3H). Mass spectrum (apci) m/z=299 (M+H-2HCl).