反应详情

2-(4-Methylthiazol-2-ylamino)pyridin-3-ol (prepared according to Example 3, Step A; 70 mg, 0.338 mmol), potassium carbonate (117 mg, 0.844 mmol) and tert-butyl 4-(bromomethyl)-1H-benzo[d]imidazole-1-carboxylate (105 mg, 0.338 mmol) [Moon, M., J. Med. Chem. (1992), 35(6), 1076] were reacted according to the method of Example 3, Steps B and C, to provide 3-((3H-benzo[d]imidazol-4-yl)methoxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine dihydrochloride (19.6 mg, 14.1% yield) as a white solid after HCl salt formation. 1H NMR (d6-DMSO) δ 9.72 (s, 1H), 7.97 (d, 1H), 7.90 (d, 1H), 7.88 (d, 1H), 7.66 (d, 1H), 7.61 (t, 1H), 7.09 (dd, 1H), 6.79 (s, 1H), 5.70 (s, 2H), 2.29 (s, 3H). Mass spectrum (apci) m/z=338.1 (M+H-2HCl).