反应详情

Methyl 3-(5-(benzyloxy)-6-(4-methylthiazol-2-ylamino)pyridin-3-ylthio)propanoate (prepared according to Example 42; 70 mg, 0.17 mmol), KOtBu (0.59 mL, 0.59 mmol) and 1-(chloromethyl)-3-methoxybenzene (0.024 mL, 0.17 mmol) were reacted according to the method of Example 43 to afford 5-(3-methoxybenzylthio)-3-(benzyloxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine hydrochloride (61.7 mg, 75.4% yield) as a white solid after HCl salt formation. 1H NMR (d6-DMSO) δ 7.84 (d, 1H), 7.57 (m, 3H), 7.44-7.33 (m, 3H), 7.17 (t, 3H), 6.80 (m, 4H), 5.29 (s, 2H), 4.17 (s, 2H), 3.68 (s, 3H), 2.30 (s, 3H); Mass spectrum (apci) m/z=450.0 (100), 359.0 (80), 238.0 (75).