反应详情

To a solution of tert-butyl {[1-{[5-(aminocarbonyl)-2-furyl]sulfonyl}-4-fluoro-5-(2-fluoropyridin-3-yl)-1H-pyrrol-3-yl]methyl}methylcarbamate (285 mg) in tetrahydrofuran (2.5 mL) were added pyridine (181 mg) and trifluoroacetic anhydride (211 mg) under ice-cooling, and the mixture was stirred for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica-gel column chromatography (eluent: hexane-ethyl acetate=6:1→3:2) to give the title compound as a pale-yellow oil (yield 258 mg, 94%).

1. temperaturecooling
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customthe residue was purified by silica-gel column chromatography (eluent: hexane-ethyl acetate=6:1→3:2)