反应详情

温度

50 °C

b-3.) 1.0 g of 2-chloro-4-(4-nitrophenyloxy)-5-trifluoromethylpyrimidine and 0.77 g of 4-amino-3-methoxy-benzoic acid benzyl ester are suspended in 15 mL of 2-propanol. The suspension is heated to 50° C. and 0.08 mL trimethylsilylchloride (TMSCl) are added. The suspension is stirred for 16 hours at 50° C. The suspension is cooled to ambient temperature and stirred for 3 hours. The precipitate is filtered and washed with 2-propanol. After drying in a vacuum drying oven 1.38 g (85% of theory) of the corresponding 2-amino pyrimidine derivative product, i.e. 3-methoxy-4-[4-(4-nitro-phenoxy)-5-trifluoromethyl-pyrimidin-2-ylamino]-benzoic acid benzyl ester is obtained.

1. temperatureThe suspension is cooled to ambient temperature
2. stirringstirred for 3 hours
3. filtrationThe precipitate is filtered
4. washwashed with 2-propanol
5. customAfter drying in a vacuum
6. dry with materialdrying oven 1.38 g (85% of theory) of the corresponding 2-amino pyrimidine derivative product