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HRID1428968

反应详情

EQUATION

反应方程式

HRID 1428968 的结构方程式

REACTANTS

反应物

3
结构：COC(=O)c1cccc(B(O)O)c1
HCID2734714

3-Methoxycarbonylphenylboronic acid

C8H9BO4

结构：CNC(=O)c1cccc(-c2ccc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)c(C)c2)c1
HCID57413864

未命名化合物

结构：CC(=O)OC[C@H]1O[C@H](Oc2ccc(Br)cc2F)[C@@H](CC(=O)[O-])[C@H](OC(C)=O)[C@H]1OC(C)=O
HCID86674307

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1cccc(-c2ccc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)c(F)c2)c1
HCID57413726

未命名化合物

收率 66%

PROCEDURE

实验过程

4a was prepared using the same procedure as for 5b with [(2R,3S,4S,5R,6R)-4,5-diacetoxy-6-(acetoxymethyl)-2-(4-bromo-2-fluoro-phenoxy)tetrahydropyran-3-yl]acetate and 3-methoxycarbonylphenyl boronic acid as the reactants. Yield: 66%. 1H NMR (300 MHz, METHANOL-d4) δ ppm 8.21 (t, J=1.65 Hz, 1H), 7.99 (td, J=1.44, 7.83 Hz, 1H), 7.84 (ddd, J=1.10, 1.92, 7.69 Hz, 1H), 7.35-7.62 (m, 4H), 5.55 (d, J=1.92 Hz, 1H), 4.10 (dd, J=1.79, 3.43 Hz, 1H), 3.94 (s, 3H), 3.86-4.00 (m, 1H), 3.59-3.86 (m, 4H). MS (ESI): found [M+Na]+, 431.1.