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HRID1428973

反应详情

EQUATION

反应方程式

HRID 1428973 的结构方程式

REACTANTS

反应物

3
结构：CNC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)cc(C(=O)NC)c1
HCID57413724

未命名化合物

结构：CNC(=O)c1cccc(-c2ccc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)c(C)c2)c1
HCID57413864

未命名化合物

结构：CC(=O)OC[C@H]1O[C@H](Oc2ccc(Br)cc2C(F)(F)F)[C@@H](CC(=O)[O-])[C@H](OC(C)=O)[C@H]1OC(C)=O
HCID86674310

未命名化合物

PRODUCTS

生成物

1
结构：CNC(=O)c1cc(C(=O)NC)cc(-c2ccc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)c(C(F)(F)F)c2)c1
HCID57413591

未命名化合物

收率 69%

PROCEDURE

实验过程

Using the procedure outlined in the synthesis of 5b with [(2R,3S,4S,5R,6R)-4,5-diacetoxy-6-(acetoxymethyl)-2-(4-bromo-2-trifluoromethyl-phenoxy)tetrahydropyran-3-yl]acetate (0.57 g) and N1,N3-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,3-dicarboxamide (9) (0.48 g), the title compound was obtained (0.340 g) in 69% yield for the two steps. 1H NMR (300 MHz, METHANOL-d4) δ ppm 8.17-8.24 (m, 1H), 8.14 (d, J=1.65 Hz, 2H), 7.92 (d, J=1.92 Hz, 1H), 7.87 (dd, J=2.20, 8.79 Hz, 1H), 7.57 (d, J=8.79 Hz, 1H), 5.64 (d, J=1.65 Hz, 1H), 4.04 (dd, J=1.65, 3.30 Hz, 1H), 3.87-3.96 (dd, 1H), 3.64-3.83 (m, 3H), 3.48-3.63 (m, 1H), 2.93 (s, 6H). MS (ESI): found: [M+H]+, 515.1.