4-Hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid 2-methyl ester → 5-(1-tert-Butoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-3-hydroxy-cyclopent-1-enecarboxylic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:11]([OH:13])=O)[CH2:7][CH:8]([OH:10])[CH:9]=1)=[O:4].[C:14]([O:18][C:19]([C@@:21]1([NH2:26])[CH2:23][C@H:22]1[CH:24]=[CH2:25])=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:11](=[O:13])[NH:26][C:21]2([C:19]([O:18][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:20])[CH2:23][CH:22]2[CH:24]=[CH2:25])[CH2:7][CH:8]([OH:10])[CH:9]=1)=[O:4]Participants
Procedure
Reaction of compound the acid 23c (50 mg, 37 mmol) with (1R,2S)-1-amino-2-vinyl-cyclopropane carboxylic acid tert-butyl ester according to the method described in Example 1 step j, provided the title compound as a slightly yellow oil (50 mg, 38%). 1H-NMR (300 MHz, CDCl3): δ [(1.38 & 1.42) s, 9H], 1.75-1.83 (m, 1H), 2.00-2.21 (m, 3H), 3.55-3.63 (m, 1H), [(3.77 & 3.82) s, 3H], 4.20-4.38 (m, 1H), 4.65-4.80 (m, 1H), 5.13-5.20 (m, 1H), 5.22-5.38 (m, 1H), 5.60-5.82 (m, 1H), 6.95-6.96 (m, 2H). Inhibitors of the invention are achieved from the title compound by coupling of the afforded cyclopentenol derivative to a desired pyrimidinol for example as described in Example 3 step f, followed by hydrolysis of the methyl ester using a reagent like LiOH; coupling of a desired alkenylamine and macrocyclisation as described in Example 3 step h and i; hydrolysis of the tert. butyl ester by treatment with for example TFA and finally coupling of a desired sulphone amide derivative for example as described in Example 3, step k.
Sources & evidence
- ORD record
- ord-94ad3078386042bea63ade5812bba90c
- Source dataset
- uspto-grants-2015_01
- Patent number
- US08937080B2
Reaction notes
Loading…