反应详情

Compound 12B was synthesized from Compound 12A in a similar manner to the procedure described for Compound 1E. 1H NMR (500 MHz, chloroform-d) δ ppm 8.17 (2H, s), 7.57 (1H, d, J=8.8 Hz), 7.18 (1H, d, J=2.5 Hz), 7.02 (1H, dd, J=8.8, 2.5 Hz), 5.36-5.44 (1H, m), 4.21 (2H, ddd, J=13.3, 6.8, 3.9 Hz), 3.62-3.73 (2H, m), 3.15-3.25 (4H, m), 3.05-3.15 (4H, m), 2.41 (2H, t, J=7.6 Hz), 2.11-2.23 (2H, m), 1.93 (2H, dddd, J=12.7, 8.4, 8.2, 4.0 Hz), 1.53-1.64 (2H, m), 0.92-0.98 (3H, m). LC/MS (m/z)=439 (M+H)+.