反应详情

Compound 21E was prepared from Compound 21D and tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate in a similar manner to the procedure described for Compound 1D in Example 1. 1H NMR (400 MHz, chloroform-d) δ ppm 8.55 (d, J=2.2 Hz, 1H), 8.17 (s, 2H), 7.93 (d, J=2.2 Hz, 1H), 6.10 (br. s., 1H), 5.52-5.66 (m, 1H), 4.21-4.33 (m, 2H), 4.12 (br. s., 2H), 3.68 (t, J=5.5 Hz, 2H), 3.50-3.64 (m, 2H), 2.56 (br. s., 2H), 2.41 (t, J=7.4 Hz, 2H), 2.24 (ddd, J=9.8, 6.2, 3.3 Hz, 2H), 1.94 (dddd, J=12.8, 8.8, 8.7, 3.8 Hz, 2H), 1.53-1.71 (m, 3H), 1.45-1.54 (m, 9H), 0.94 (t, J=7.4 Hz, 3H). LC/MS (m/z)=537 (M+H)+.