Hydrochloric Acid → 4-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butanoic acid

HRID 1429574Notes

Reaction equation

HRID 1429574 reaction equation
[CH2:1]([C:4]1[CH:5]=[N:6][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([O:16][C:17]3[S:18][C:19]4[CH:25]=[C:24]([C:26]5[CH2:31][CH2:30][N:29]([S:32]([CH2:35][CH2:36][CH2:37][C:38]([O:40]C)=[O:39])(=[O:34])=[O:33])[CH2:28][CH:27]=5)[CH:23]=[CH:22][C:20]=4[N:21]=3)[CH2:12][CH2:11]2)=[N:8][CH:9]=1)[CH2:2][CH3:3].[OH-].[Li+].Cl>C1COCC1>[CH2:1]([C:4]1[CH:5]=[N:6][C:7]([N:10]2[CH2:11][CH2:12][CH:13]([O:16][C:17]3[S:18][C:19]4[CH:25]=[C:24]([C:26]5[CH2:31][CH2:30][N:29]([S:32]([CH2:35][CH2:36][CH2:37][C:38]([OH:40])=[O:39])(=[O:34])=[O:33])[CH2:28][CH:27]=5)[CH:23]=[CH:22][C:20]=4[N:21]=3)[CH2:14][CH2:15]2)=[N:8][CH:9]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68208471Methyl 4-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butanoate2×

Product 1

HCID 674656774-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butanoic acidYield 79.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl 4-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butanoate (Compound 47A, 268 mg, 0.447 mmol) in THF (3 mL) was added sat. aq. lithium hydroxide (1 mL). The reaction mixture was stirred at rt for 6 h. The reaction mixture was neutralized with cool aq. HCl (1 N) and extracted with CH2Cl2 (3×3 mL). The combined organic layers were washed with brine, dried (Na2SO4), filtered, and concentrated. The crude product was recrystallized from 10% water in CH3CN to afford 4-(4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridin-1(2H)-ylsulfonyl)butanoic acid (218 mg, 0.354 mmol, 79% yield) as a white solid. 1H NMR (500 MHz, CDCl3) δ ppm 8.25 (br. s., 2H), 7.60-7.66 (m, 2H), 7.39 (dd, J=8.5, 1.9 Hz, 1H), 6.01-6.12 (m, 1H), 5.43-5.53 (m, J=7.3, 3.6, 3.6, 3.4 Hz, 1H), 4.17-4.28 (m, 2H), 3.98-4.07 (m, 2H), 3.60 (t, J=5.8 Hz, 2H), 3.07-3.15 (m, 2H), 2.68 (d, J=1.7 Hz, 2H), 2.58-2.64 (m, 2H), 2.46 (t, J=7.6 Hz, 2H), 2.10-2.26 (m, 5H), 1.95-2.08 (m, 2H), 1.50-1.66 (m, 4H), 0.96 (t, J=7.4 Hz, 3H). LCMS (m/z)=586 (M+H)+.

Workup

  1. extractionextracted with CH2Cl2 (3×3 mL)
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe crude product was recrystallized from 10% water in CH3CN

Sources & evidence

ORD record
ord-787786c267cf45c8aab48621820ca4e9
Source dataset
uspto-grants-2015_01
Patent number
US08940716B2

Reaction notes

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