反应详情

To a solution of tert-butyl 4-(2-(1-((2-(trimethylsilyl)ethoxy)carbonyl)-piperidin-4-yloxy)benzo[d]thiazol-6-yl)-5,6-dihydropyridine-1 (2H)-carboxylate (555 mg, 0.991 mmol) in ethyl acetate (10 mL) was added Pd/C (10%, 2.638 g, 2.48 mmol). The mixture was charged with a balloon of H2 and stirred at rt overnight. The reaction mixture was filtered through a pad of celite and rinsed with EtOAc. The filtrate was concentrated to afford tert-butyl 4-(2-(1-((2-(trimethylsilyl)ethoxy)carbonyl)piperidin-4-yloxy)benzo[d]thiazol-6-yl)piperidine-1-carboxylate (385 mg, 0.685 mmol, 69% yield) as a gray gum. LCMS (m/z)=562 (M+H)+.

1. additionThe mixture was charged with a balloon of H2
2. filtrationThe reaction mixture was filtered through a pad of celite
3. washrinsed with EtOAc
4. concentrationThe filtrate was concentrated