反应详情

温度

0 °C

A mixture of 5,6-diamino-3-propyl-1H-pyrimidine-2,4-dione (4.25 g, 0.023 mol), 1-(3-Trifluoromethyl-benzyl)-1H-pyrazole-4-carboxylic acid (6.23 g, 0.023 mol), prepared by conventional methods starting from pyrazole-4-carboxylic ester, in methanol (50 ml) were cooled to 0° C. and added EDCI.HCl (8.82 g, 0.046 mol). The reaction mixture was stirred at 25° C. for 6 h and the organic volatiles were evaporated. To this residue water (50 ml) was added and the precipitate was filtered off, and washed with cold water (50 ml) to obtain 1-(3-Trifluoromethyl-benzyl)-1H-pyrazole-4-carboxylic acid (6-amino-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide (7.2 g, 72%) as a pale yellow solid.

1. customprepared by conventional methods
2. customthe organic volatiles were evaporated
3. additionTo this residue water (50 ml) was added
4. filtrationthe precipitate was filtered off
5. washwashed with cold water (50 ml)