反应详情

The tert-butyl-4-(4-chlorophenylamino)piperidine-1-carboxylate (973.2 mg, 3.1 mmol) obtained in step 1 was dissolved in ethyl acetate and mixed at 0 C for 3 hr with 6N HCl (5 mL), with stirring, after which distilled water was added to terminate the reaction. The resulting reaction mixture was washed with ethyl acetate. The pH of the aqueous layer thus formed was adjusted to 10 to 12 with 2N sodium hydroxide, followed by washing with ethyl acetate and saline to separate an organic solvent layer. This organic solvent layer was dried over anhydrous magnesium sulfate and evaporated at reduced pressure to afford N-(4-chlorophenyl)piperidine-4-amine (yield 87%).

1. distillationafter which distilled water
2. additionwas added
3. customto terminate
4. customthe reaction
5. customThe resulting reaction mixture
6. washwas washed with ethyl acetate
7. customThe pH of the aqueous layer thus formed
8. washby washing with ethyl acetate and saline
9. customto separate an organic solvent layer
10. dry with materialThis organic solvent layer was dried over anhydrous magnesium sulfate
11. customevaporated at reduced pressure