huagongshe.com
HRID1430817

反应详情

EQUATION

反应方程式

HRID 1430817 的结构方程式

REACTANTS

反应物

2
结构：CO.O=C=O
HCID21973728

未命名化合物

结构：COC(=O)N[C@@H]1CCN(c2cc(C#N)cc(N)c2Cl)C[C@H]1O[Si](C)(C)C(C)(C)C
HCID131732376

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)N[C@H]1CCN(c2cc(C#N)cc(N)c2Cl)C[C@@H]1O[Si](C)(C)C(C)(C)C
HCID89919054

未命名化合物

收率 43.8%

PROCEDURE

实验过程

(+/−)-methyl ((3R,4R)-1-(3-amino-2-chloro-5-cyanophenyl)-3-((tert-butyl dimethylsilyl)oxy)piperidin-4-yl)carbamate (Example 171E, 927 mg, 2.112 mmol) was separated by chiral SFC (Berger SFC MGIII, Column: Lux Cel-425×3 cm ID, 5 μm; Flow rate: 85.0 mL/min; Mobile Phase: 85/15 CO2/methanol; Detector Wavelength: 220 nm). Methyl ((3S,4S)-1-(3-amino-2-chloro-5-cyanophenyl)-3-((tert-butyldimethylsilyl)oxy)piperidin-4-yl)carbamate (406 mg) was obtained as a white foaming solid. The enantiomeric purity of each fraction was estimated to be greater than 99.5%.