反应详情

methyl ((3R,4R)-3-((tert-butyldimethylsilyl)oxy)-1-(2-chloro-5-cyano-3-((7-cyano-4-(ethyl(4-m ethoxybenzyl)amino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperidin-4-yl)carbamate (140 mg, 0.188 mmol) was dissolved into Tetrahydrofuran (2 mL). TBAF 1M in THF (0.244 mL, 0.244 mmol) was added. The mixture was stirred at r.t. overnight. The mixture was concentrated to dryness, then diluted with EtOAc (50 ml) and washed with sat. NaHCO3. The water layer was extracted with 20 ml EtOAc. The combined organic layer was washed with brine, dried over MgSO4, filtered and concentrated to dryness to give 128 mg of product, which was used further without purification.

1. concentrationThe mixture was concentrated to dryness
2. additiondiluted with EtOAc (50 ml)
3. washwashed with sat. NaHCO3
4. extractionThe water layer was extracted with 20 ml EtOAc
5. washThe combined organic layer was washed with brine
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated to dryness