tert-Butyl piperazine-1-carboxylate → Tert-butyl 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)piperazine-1-carboxylate

HRID 1431625Notes

Reaction equation

HRID 1431625 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[N:16]1([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>C(O)(C)C>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([N:19]2[CH2:18][CH2:17][N:16]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:21][CH2:20]2)[C:11]=1[CH3:12]

Participants

4

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

Product 1

HCID 59631055Tert-butyl 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)piperazine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Essentially prepared according to Procedure G using 2,4-dichloro-5,7-difluoro-3-methylquinoline (610.0 mg, 2.50 mmol) and tert-butyl piperazine-1-carboxylate in isopropanol to give tert-butyl 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)-piperazine-1-carboxylate. Mass Spectrum (ESI) m/e=398.2 (M+1).

Workup

  1. customEssentially prepared

Sources & evidence

ORD record
ord-181d624eaea6462e8a46a3bef88f5c01
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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