2,2-Dimethylpropyl carbonochloridate → HCID 57449774, compound

HRID 1431668Notes

Reaction equation

HRID 1431668 reaction equation
[F:1][C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[C:4]([NH:20][C:21]1[CH:22]=[N:23][CH:24]=[C:25]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[CH:26]=1)=[C:5]([CH3:19])[C:6]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[N:7]2.Cl[C:34]([O:36][CH2:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:35]>>[F:1][C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[C:4]([NH:20][C:21]1[CH:22]=[N:23][CH:24]=[C:25]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)[CH:26]=1)=[C:5]([CH3:19])[C:6]([N:13]1[CH2:14][CH2:15][N:16]([C:34]([O:36][CH2:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:35])[CH2:17][CH2:18]1)=[N:7]2

Participants

3

Reactant 2

HCID 33521852,2-Dimethylpropyl carbonochloridateHCID 596310285,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine

Product 1

HCID 57449774HCID 57449774, compound

Procedure

Prepared according to Procedure N using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50 mg, 0.11 mmol) and neopentyl chloroformate to give neopentyl 4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazine-1-carboxylate. 1H NMR (DMSO-d6) δ ppm 0.93 (br s, 9H), 2.09 (br s, 3H), 3.05 (t, J=4.4 Hz, 4H), 3.29-3.33 (m, 4H), 3.58 (br s, 4H), 3.69 (t, J=4.4 Hz, 4H), 3.74 (s, 2H), 6.50 (s, 1H), 7.14-7.19 (m, 1H), 7.30-7.28 (m, 1H), 7.51 (d, J=2 Hz, 1H), 7.78 (d, J=2.4 Hz, 1H), 8.36 (s, 1H). Mass Spectrum (ESI) m/e=555.3 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1054b73f8697491791c820947a0d4532
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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