反应详情

Benzyl bromide (35.6 mL, 0.3 mol) was added to a suspension of 2,4-dihydroxyacetophenone (15 g, 0.1 mol) and potassium carbonate (41.4 g, 0.3 mol) in acetonitrile (150 mL) and the mixture stirred overnight. After concentration to dryness, the residues were resuspended in dichloromethane (100 mL) and washed with water (100 mL). The organic phase was dried over magnesium sulphate and concentrated. Trituration with hexanes, filtration and drying in vacuo gave 1-(2,4-Bis-benzyloxyphenyl)-ethanone as a white powder (26 g).

1. concentrationAfter concentration to dryness
2. washwashed with water (100 mL)
3. dry with materialThe organic phase was dried over magnesium sulphate
4. concentrationconcentrated
5. filtrationTrituration with hexanes, filtration
6. customdrying in vacuo