反应详情

To a solution of tris(methylthio)methane (0.640 g, 4.15 mmol) in THF (12 mL) at −78° C. was added n-butyllithium (1.6 mL, 4.15 mmol). After stirring for 30 min, 2-[2-(4-trifluoromethyl-phenoxymethyl)-1H-benzoimidazol-5-yl]-benzaldehyde (0.274 g, 0.691 mmol, Example 9, Step A) in THF (2 mL) was carefully added to the reaction mixture at −78° C. After 20 min, the reaction was quenched by addition of methanol. The reaction mixture was purified by chromatography (silica, hexanes: EtOAc, 2:1) to afford the title compound as a yellow oil (0.836 g, 94%).

1. waitAfter 20 min
2. customthe reaction was quenched by addition of methanol
3. customThe reaction mixture was purified by chromatography (silica, hexanes: EtOAc, 2:1)