反应详情

Prepared by the same method as described in example 48 except that (i) after step 3, and prior to step 4, (2S,3S)-2-amino-N-(2-fluoro-4-iodo-phenyl)-3-phenyl-butyramide was converted to (2S,3S)-2-amino-N-(2-fluoro-4-trimethylsilanylethynyl-phenyl)-3-phenyl-butyramide under the conditions described below, and (ii) after initial purification in step 6 the product was subjected to chiral HPLC separation as described below. The trimethylsilyl group introduced in step 3 was subsequently removed during step 5 of the synthesis, concomitant with removal of the tert-butyloxycarbonyl protecting group.

1. customPrepared by the same method
2. custompurification in step 6 the product
3. customwas subjected to chiral HPLC separation
4. additionThe trimethylsilyl group introduced in step 3
5. customwas subsequently removed during step 5 of the synthesis, concomitant with removal of the tert-butyloxycarbonyl protecting group