4-tert-Butylbenzylamine → HCID 178440915, compound

HRID 1434717Notes

Reaction equation

[Cl:1][C:2]1[C:3]([C:8]2[CH:19]=[CH:18][C:11]3[C:12](O)=[N:13][S:14](=[O:16])(=[O:15])[C:10]=3[CH:9]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.[C:20]([C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1)([CH3:23])([CH3:22])[CH3:21]>>[C:20]([C:24]1[CH:25]=[CH:26][C:27]([CH2:28][NH:29][C:12]2[C:11]3[CH:18]=[CH:19][C:8]([C:3]4[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][N:4]=4)=[CH:9][C:10]=3[S:14](=[O:16])(=[O:15])[N:13]=2)=[CH:30][CH:31]=1)([CH3:23])([CH3:21])[CH3:22]

Participants

Reactant 2

HCID 27356554-tert-Butylbenzylamine

HCID 178527199HCID 178527199, compound

Product 1

HCID 178440915HCID 178440915, compound

Procedure

The title compound was prepared by reacting the product of Example 1B (0.1507 g, 0.51 mmol) with 4-tert-butylbenzylamine (0.1070 g, 0.66 mmol) using the procedure as described in Example 1C. MS (ESI+) m/z 440 (M+H)+; (ESI−) m/z 438 (M−H)−; 1H NMR (300 MHz, CDCl3) δ 1.33 (s, 9H), 4.79 (d, J=5.4 Hz, 2H), 6.14 (t, J=5.3 Hz, 1H), 7.32 (dd, J=8.0, 4.6 Hz, 1H), 7.37 (m, 2H), 7.44 (m, 2H), 7.57 (d, J=8.1 Hz, 1H), 7.85 (dd, J=8.1, 1.4 Hz, 1H), 8.03 (dd, J=8.1, 1.4 Hz, 1H), 8.34 (d, J=1.0 Hz, 1H), 8.62 (dd, J=4.4, 1.4 Hz, 1H).

Sources & evidence

ORD record: ord-fa9aeb074f9c4966b906dbacad495553
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615570B2

Reaction notes

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