反应详情

The 3-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(methylthio)benzoylamino]-N-(5-chloropyridin-2-yl)pyridine-2-carboxamide (184 mg, 0.31 mmol) was dissolved in TFA (4 mL). After 5 minutes, the reaction was concentrated in vacuo. The residue was diluted with dichloromethane (100 mL) and extracted with saturated aqueous sodium carbonate (2×10 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated to give the desired product as a white solid (139 mg, 0.28 mmol, 90%).

1. concentrationthe reaction was concentrated in vacuo
2. additionThe residue was diluted with dichloromethane (100 mL)
3. extractionextracted with saturated aqueous sodium carbonate (2×10 mL)
4. dry with materialThe organic layer was dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated