反应详情

{4-[5-(3-Amino-3-methyl-but-1-ynyl)-thiophen-2-yl]-pyrimidin-2-yl}-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine (Example 5, 100 mg, 0.252 mmol) in MeOH (100 ml) was hydrogenated over Pd/C (10%, 50 mg) at 1 atm for 2 hours. The reaction mixture was filtered, evaporated to dryness and purified via chromatography on silicagel (DCM/MeOH/ammonia: 95/5/1 to 90/10/1) to give the title compound as colorless solid, which crystallized from ether.

1. filtrationThe reaction mixture was filtered
2. customevaporated to dryness
3. custompurified via chromatography on silicagel (DCM/MeOH/ammonia: 95/5/1 to 90/10/1)