反应详情

The title compound is prepared starting from (S)-3-(aminomethyl)-1-N-tert-butyloxycarbonylpyrrolidine following the procedures described in Example 11, except 3,5-dichlorobenzaldehyde replaces 2,4-dichlorobenzaldehyde in step (i). The L-tartrate salt is obtainable by freeze-drying from water-acetonitrile. 1H NMR (300 MHz, DMSO) δH: 7.45 (1H, s), 7.34 (2H, s), 3.88 (2H, s), 3.55 (2H, s), 3.22-3.01 (3H, m), 2.83-2.72 (2H, m), 2.37 (3H, brs), 1.98-1.91 (1H, m), 1.60-1.45 (1H, m), 0.97 (6H, m). LCMS: Rt=3.17 (12 min method) [M+H]=301/3.

1. dry with materialby freeze-drying from water-acetonitrile
2. customRt=3.17 (12 min method) [M+H]=301/3