反应详情

The title compound is prepared starting from (S)-3-(aminomethyl)-1-N-tert-butyloxycarbonylpyrrolidine following the procedures described in Example 11 except 3,5-dichlorobenzaldehyde replaces 2,4-dichlorobenzaldehyde in step (i) and propionaldehyde replaces acetone in step (ii). The L-tartrate salt is obtainable by freeze-drying from water-acetonitrile. 1H NMR (300 MHz, DMSO) δH: 7.47 (1H, s), 7.34 (2H, s), 3.83 (2H, s), 3.54 (2H, s), 3.27-3.21 (1H, m), 3.20-3.05 (2H, m), 2.76-2.70 (1H, m), 2.44-2.29 (5H, m), 2.08-1.85 (1H, m), 1.54-1.37 (3H, m), 0.82-0.78 (3H, m). LCMS: Rt=3.42 (12 min method) [M+H]=301/3.

1. dry with materialby freeze-drying from water-acetonitrile
2. customRt=3.42 (12 min method) [M+H]=301/3