Aluminium lithium hydride → 2-{[4-(4-Bromophenyl)-1,3-thiazol-2-yl]amino}-3,3,3-trifluoropropan-1-ol

Temperature

0 °C

Methyl N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3,3,3-trifluoroalaninate (1.08 g, 2.70 mmol), prepared in the previous step, was dissolved in 50 mL of tetrahydrofuran and cooled to 0° C. Lithium aluminum hydride (1M solution in tetrahydrofuran, 5.5 mL, 5.5 mmol) was added slowly and the mixture was stirred for 30 min. The reaction was then quenched by careful addition of 0.2 mL H2O, followed by 0.2 mL of 15% aqueous KOH, then an additional 0.6 mL of H2O and the mixture was stirred for 30 min. The reaction mixture was diluted with ethyl acetate and filtered through the Celite™ reagent. The filtrate was washed with brine, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. Flash chromatography (15% acetone/hexane) provided 2-{[4-(4-bromophenyl)-1,3-thiazol-2-yl]amino}-3,3,3-trifluoropropan-1-ol (0.67 g, 68%) as a white solid, mp 133-134° C.; MS (ESI) m/z 367. HRMS: calcd for C12H10BrF3N2OS+H, 366.97275; found (ESI, [M+H]+), 366.9712. Analytical HPLC: retention time 10.0 min, 210-370 nm the Xterra® RP18 column, 3.5μ, 150×4.6 mm 40° C. 85/15-5/95 (Ammon. Form. Buff. pH=3.5/ACN+MeOH) for 10 min, hold 4 min, 1.2 mL/min 5 μL injection.

1. customThe reaction was then quenched by careful addition of 0.2 mL H2O
2. stirringan additional 0.6 mL of H2O and the mixture was stirred for 30 min
3. additionThe reaction mixture was diluted with ethyl acetate
4. filtrationfiltered through the Celite™ reagent
5. washThe filtrate was washed with brine
6. dry with materialdried over anhydrous MgSO4
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure

ORD record

ord-4183e15c65674f8786d1b128547b3801

Source dataset

uspto-grants-2009_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07618990B2