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HRID1437814

反应详情

EQUATION

反应方程式

HRID 1437814 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)[Si](C)(C)Oc1ccc([C@@H]2[C@@H](CC[C@H](O)c3ccc(F)cc3)C(=O)N2c2ccc(C#CCNS(C)(=O)=O)cc2)cc1
HCID68975379

未命名化合物

PRODUCTS

生成物

1
结构：CS(=O)(=O)NCC#Cc1ccc(N2C(=O)[C@H](CC[C@H](O)c3ccc(F)cc3)[C@H]2c2ccc(O)cc2)cc1
HCID67055618

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

To a solution of 10 mg of N-[3-(4-{(2S,3R)-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxoazetidin-1-yl}phenyl)prop-2-yn-1-yl]methanesulfonamide in 0.5 mL THF was added 0.5 mL of 2N aq. HCl. The resulting mixture was stirred at room temperature for 1 hr at which time the volatiles were removed under vacuum. The residue was purified by prep. Tlc eluting with CH2Cl2/MeOH (9/1) followed by further purification by prep. Tlc eluting with CH2Cl2/MeOH (95/5) afforded the title compound. m/z (ES) 544.9 (M+Na+), 523 (MH+), 505 (M−H2O+).

WORKUP

后处理

  1. customwere removed under vacuum
  2. customThe residue was purified by prep
  3. customTlc eluting with CH2Cl2/MeOH (9/1) followed by further purification by prep