反应详情

温度

25 °C

A mixture of tert-butyl (2R)-2-[({7-(benzyloxy)-4-[3-chloro-4-fluoroanilino]-quinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate (230 mg) (obtained as described in Example 16) and 5% palladium on carbon in ethanol (5 ml) was stirred under hydrogen (5 bar pressure) at 25° C. for 16 hours. The mixture was then filtered and concentrated in vacuo to leave the tert-butyl (2R)-2-[({4-[3-chloro-4-fluoroanilino]-7-hydroxyquinazolin-5-yl}oxy)methyl]pyrrolidine-1-carboxylate as a light brown oil, which was used without further purification.

1. filtrationThe mixture was then filtered
2. concentrationconcentrated in vacuo