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HRID1444049

反应详情

EQUATION

反应方程式

HRID 1444049 的结构方程式

REACTANTS

反应物

2
结构：CNC(=O)CS
HCID4047279

Acetamide, 2-mercapto-N-methyl-

C3H7NOS

结构：COc1nc(Br)cnc1N(COCC[Si](C)(C)C)S(=O)(=O)c1cccc(Cl)c1Cl
HCID59168156

未命名化合物

PRODUCTS

生成物

1
结构：CNC(=O)CSc1cnc(NS(=O)(=O)c2cccc(Cl)c2Cl)c(OC)n1
HCID59168207

未命名化合物

PROCEDURE

实验过程

Prepared as for Example 101b using N-(5-bromo-3-methoxy-2-pyrazinyl)-2,3-dichloro-N-[{2-(trimethylsilanyl)ethoxy}methyl]benzenesulphonamide (Example 55a) (0.4 g) and 2-mercapto-N-methylacetamide (0.1 g). The intermediate product containing the SEM (2-[trimethylsilyl]ethoxymethyl) group was purified by silica gel chromatography eluting with ethyl acetate/iso-hexane mixtures. Deprotection as for Example 101b gave the title compound. Yield 0.05 g.

WORKUP

后处理

  1. customPrepared as for Example 101b
  2. additionThe intermediate product containing the SEM (2-[trimethylsilyl]ethoxymethyl) group
  3. customwas purified by silica gel chromatography
  4. washeluting with ethyl acetate/iso-hexane mixtures