反应详情

4-[N-Methyl-N-(5-chloro-2-benzoxazolyl)amino]phenol (0.00255 mol, 0.7 g, prepared as above), ethyl 2-bromopropionate (0.00255 mol, 0.46 g) and potassium carbonate (0.00255 mol, 0.35 g) were mixed in methyl ethyl ketone (5 ml) and heated under reflux for 6 hours. The solvent was then evaporated, the residue taken into water (25 ml) and twice extracted with diethyl ether (25 ml). An oily residue was obtained which was purified by preparative thin layer chromatography on silica gel, eluent toluene/diethyl ether. Yield 0.75 g, mp 68.0°-68.6° C.; ir, and pmr spectra and analysis consistent with assigned structure.

1. temperatureheated
2. temperatureunder reflux for 6 hours
3. customThe solvent was then evaporated
4. extractiontwice extracted with diethyl ether (25 ml)
5. customAn oily residue was obtained which
6. customwas purified by preparative thin layer chromatography on silica gel, eluent toluene/diethyl ether