反应详情

To the above acid (1 g, 4.6 mmol) in 12 ml THF is added 8 ml of DMF and potassium carbonate (0.63 g, 5 mmol) followed by α-cyano-m-phenoxybenzyl mesylate (1.31 g, 5 mmol). The reaction mixture is stirred, under nitrogen, at RT for 20 hours. The reaction mixture is then diluted with ether. The organic layer is washed with water and brine, dried and solvent removed under vacuum. The residue is purified by prep. TLC to give α-cyano-m-phenoxybenzyl 2-(2-isoindolinyl)-3-methylbutanoate.

1. washThe organic layer is washed with water and brine
2. customdried
3. customsolvent removed under vacuum
4. customThe residue is purified by prep