反应详情

74.2 G. of 2-(4-n-butylphenyl)-3-ethoxy-acrolein, 77.8 g. of the 4-amidinobenzoic acid amide hydrochloride described earlier and 0.546 mol of sodium methylate (obtained by dissolving 12.55 g. of sodium metal in methanol) are suspended in 2500 ml. of methanol and stirred overnight at room temperature under an atmosphere of nitrogen. The yellow suspension is subsequently removed by filtration, washed with a small amount of ethanol and suspended in 4 liters of ether for further purification. The suspension is washed with water and then filtered again. Sparingly soluble 4-[5-(4-n-butylphenyl)-2-pyrimidinyl] benzoic acid amide is obtained.

1. customThe yellow suspension is subsequently removed by filtration
2. washwashed with a small amount of ethanol
3. customsuspended in 4 liters of ether for further purification
4. washThe suspension is washed with water
5. filtrationfiltered again