反应详情

5.5 g (30.3 mmol) of the chloride from Example 1, Step B and 6.3 g (30.3 mmol) of 4-aminomethyl-2'-cyanobiphenyl (prepared according to EP 459 136) were heated in 150 ml dry ethanol for 10 h. After removal of the solvent in vacuo yellow crystals formed. These were purified by suspension in acetone and dissolved, in ethyl acetate. The solution was washed with 10% sodium carbonate solution, the organic layer dried over sodium sulfate, and evaporated to dryness to give colorless crystals of the title compound, m.p. 230°-233° C.

1. customAfter removal of the solvent in vacuo yellow crystals
2. customformed
3. customThese were purified by suspension in acetone
4. dissolutiondissolved, in ethyl acetate
5. washThe solution was washed with 10% sodium carbonate solution
6. dry with materialthe organic layer dried over sodium sulfate
7. customevaporated to dryness