反应详情

100 mg (0.16 mmol) of 3-[3-(3-{3-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenoxy}-propoxy)-phenyl]-propionic acid ethyl ester in 10 mL of EtOAc were hydrogenated in the presence of 60 mg of 10% Pd/C. After removal of the catalyst and evaporation of the solvent, the residue was purified by column chromatography on silica gel with a gradient of EtOAc/n-heptane 1:5 to 1:3 to yield 64 mg (80%) of 3-(3-{3-[3-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenoxy]-propoxy}-phenyl)-propionic acid ethyl ester as a colorless oil, MS: 493 (M−H)−.

1. customAfter removal of the catalyst and evaporation of the solvent
2. customthe residue was purified by column chromatography on silica gel with a gradient of EtOAc/n-heptane 1:5 to 1:3